Oral steroids

Steroid preparations intended for oral administration represent steroid molecules thus modified to make them more resistant to passage of the liver and prevent their premature removal from the blood. This modification is almost always accomplished by the addition of an alkyl (methyl) group at the 17th position of the steroid ring. In this case, the liver can still lower the level of AAS concentration in the blood, but not as effectively as un-modified analogues. Therefore, oral steroids can do several cycles of passage with blood through the liver before they are eliminated from the body. Most oral steroid drugs are excreted from the body without changes, albeit at different rates.

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