Melanotan I

Melanotan 1 – peptide, a synthetic analogue of the natural melanocortin (peptide which stimulates melanin synthesis, and determine the skin sunburn), has properties aphrodisiac that supported by research.So far, there is no drug approved for use in humans, only laboratory substance used for clinical trials, in spite of this Melanotan 2 is actively spreading on the network, creating a high risk of counterfeit products. 

History

Melanotan 2 was first synthesized in the University of Arizona, as a means for protection against skin cancer (as melanin pigment has a protective function, not passing ultraviolet rays). Scientists have found that the natural melanocortin has a short half life, so it can not be used as a drug, it was therefore decided to modify its formula to enhance the stability of the molecule. After synthesis and screening of large numbers of substances held J. Hruby and Victor Mac E. Hadley, was discovered peptide [Nle4, D-Phe7] -α -MSH, which was approximately 1000 times more potent than natural melanocortin. Later, he was called Melanotan 2 and has been patented. 

Melanotan-1 (or afamelanotide) is completely analogous peptide was Phase 3 clinical trials approved for use in humans under the trade mark Scenesse.

Effects

  • It causes pigmentation of the skin due to the formation of melanin (tan pharmacological)
  • It increases libido and erection increases (within 2 hours after the first injection)
  • suppresses appetite
  • Promotes fat burning

Side effects 

Peptide is not approved by the FDA for use in humans. Known side effects Melanotan 2:

  • erythema
  • Nausea
  • Fever
  • Dark spots on the skin, which can increase in size (is reversible). 
  • Theoretically, the damage to the immune system and the complications of the cardiovascular system However, it was revealed in studies that stimulation of melanocytes does not ozlakochestvleniyu. 
  • prolonged erection

Completed Phase 3 clinical trials of Melanotan 1, approved for use Medicines Agency European (EMA) Name Review Group (NRG) , which is a significant safety confirmation.

Course

Single the daily dose of Melanotan 2 is 500-1000 .mu.g to achieve the desired shade tan (15-20 days). The first injection is best carried out with a low dose of 100-200 mg to assess individual tolerance. The exact calculation of per kilogram of body weight is not required, as the doses vary widely. The results appear gradually over 1-3 weeks. To accelerate pigmentation can visit a solarium or sunbathe. The peptide is administered subcutaneously insulin syringe is dissolved in water for injection.

Storage and preparation of the solution

According to the recommendations Yu BOMBEL necessary to cool the flask to room temperature, and enter a desired volume of water for injection (which must flow down the wall of the vial), and then stir the rotary motion (not shaking). The prepared solution can be stored for 14-20 days in the refrigerator.

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